Methanol → HCID 86250420, 화합물

HRID 2232094노트

반응식

HRID 2232094 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=[N:9][OH:10])[CH3:8])=[CH:3][CH:2]=1.[BH4-].[Na+].[CH3:13]O>>[CH3:13][N:1]1[CH2:6][CH:5]=[C:4]([C:7](=[N:9][OH:10])[CH3:8])[CH2:3][CH2:2]1

참가 물질

4

반응물 3

HCID 887Methanol2회HCID 247997Ethanone, 1-(4-pyridinyl)-, oximeHCID 4311764Sodium borohydride

생성물 1

HCID 86250420HCID 86250420, 화합물

실험 절차

A solution of 1-(4-pyridinyl)ethanone oxime, methiodide (48.36 g, 174 mmol) in 200 ml of 50% aqueous methanol was added to a cooled (-5° C.) slurry of sodium borohydride (12.86 g, 340 mmol) in 200 ml 50% aqueous methanol and the reaction mixture was stirred one hour. After some inorganic material was removed by filtration, the methanol was distilled off the filtrate in vacuo. The resulting solid was collected by filtration and dried to provide 1-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)ethanone oxime (18 g), mp 166°-168° C.

후처리

  1. customAfter some inorganic material was removed by filtration
  2. distillationthe methanol was distilled off the filtrate in vacuo
  3. filtrationThe resulting solid was collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-bcac5a59686941e4b9bbd19029e6859a
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04786648

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