Dicyclohexylcarbodiimide → 2,5-Dimethylcyclopentyl N-t-butoxycarbonyl-1-aminocyclopropanecarboxylate

HRID 2232692

반응식

HRID 2232692 반응식
[CH3:1][CH:2]1[CH2:6][CH2:5][CH:4]([CH3:7])[CH:3]1[OH:8].[C:9]([O:13][C:14]([NH:16][C:17]1([C:20](O)=[O:21])[CH2:19][CH2:18]1)=[O:15])([CH3:12])([CH3:11])[CH3:10].C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[C:9]([O:13][C:14]([NH:16][C:17]1([C:20]([O:8][CH:3]2[CH:4]([CH3:7])[CH2:5][CH2:6][CH:2]2[CH3:1])=[O:21])[CH2:19][CH2:18]1)=[O:15])([CH3:12])([CH3:11])[CH3:10]

참가 물질

6

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 6883961-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acidHCID 133801502,5-Dimethylcyclopentan-1-ol

생성물 1

HCID 212439622,5-Dimethylcyclopentyl N-t-butoxycarbonyl-1-aminocyclopropanecarboxylate

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 2,5-dimethylcyclopentanol (0.55 g), compound 1 (0.97 g), and 4-(dimethylamino)pyridine (0.06 g.) in methylene chloride (100 ml) was added dicyclohexylcarbodiimide (1.09 g.), and the resulting mixture was stirred overnight. The precipitated dicyclohexylurea was removed by filtration, and the filtrate was evaporated. Ethyl acetate was then added to the residue, and the mixture was filtered again. The filtrate was washed with 1M hydrochloric acid, saturated aqueous sodium bicarbonate, and water, dried over magnesium sulfate, and the solvent was evaporated to a colorless oil (1.18 g. 83%). The product was purified by column chromatography on silica gel, 4:1 hexane:ethyl acetate, eluent.

후처리

  1. customThe precipitated dicyclohexylurea was removed by filtration
  2. customthe filtrate was evaporated
  3. additionEthyl acetate was then added to the residue
  4. filtrationthe mixture was filtered again
  5. washThe filtrate was washed with 1M hydrochloric acid, saturated aqueous sodium bicarbonate, and water
  6. dry with materialdried over magnesium sulfate
  7. customthe solvent was evaporated to a colorless oil (1.18 g. 83%)
  8. customThe product was purified by column chromatography on silica gel, 4:1 hexane

출처 및 근거

ORD 기록
ord-ba7a58116e30486790ae07009ec089d7
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04788332

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