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Diisopropylamine → 3,3-Bis(3-chlorophenyl)-2-propenal

HRID 2232736
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HRID 2232736 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=1)=O.C(NC(C)C)(C)C.C([Li])CCC.ClP(=O)(OCC)[O:31][CH2:32][CH3:33]>CCCCCC.C(N=CC)(C)(C)C.O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=2)=[CH:33][CH:32]=[O:31])[CH:14]=[CH:15][CH:16]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 7912DiisopropylamineHCID 13139Diethyl chlorophosphateHCID 3483033,3'-DichlorobenzophenoneHCID 178418339Butyllithium

생성물 1

HCID 145472273,3-Bis(3-chlorophenyl)-2-propenal

시약·촉매·용매 3

HCID 8028Tetrahydrofuran용매
HCID 8058
Hexane
용매
HCID 138901N-Ethylidene-2-methylpropan-2-amine용매

실험 절차

The compound was prepared according to the procedure described in Example 84. The following reagents were used: 3,3'-dichlorobenzophenone (25.1 g), diisopropylamine (32.2 mL), 1.6M n-butyl lithium in hexane (144 mL), acetaldehye N-tertbutylimine (14.75 mL), diethyl chlorophosphonate (16.6 mL) and tetrahydrofurane (200 mL). The usual work up furnished 24.0 g of essentially pure 3,3-bis(3-chlorophenyl)-2-propenal as an orange oil.

후처리

  1. customThe compound was prepared

출처 및 근거

ORD 기록
ord-43311cba43f94a1ea0a4c62ee103da3c
출처 데이터셋
uspto-grants-1988_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04788206

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