tert-Butyl methyl ether → 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-propyl-2H-1-benzopyran-2-one

HRID 22330

반응식

HRID 22330 반응식
CS(O[CH2:6][CH2:7][CH2:8][O:9][C:10]1[C:11]([O:24][CH3:25])=[CH:12][C:13]2[O:18][C:17](=[O:19])[CH:16]=[C:15]([CH2:20][CH2:21][CH3:22])[C:14]=2[CH:23]=1)(=O)=O.[C:26]1([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.CC(OC)(C)C.C([O-])(=O)/C=C/C([O-])=O>CO.CC(C)=O>[CH3:25][O:24][C:11]1[C:10]([O:9][CH2:8][CH2:7][CH2:6][N:35]2[CH2:36][CH2:37][CH:32]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:33][CH2:34]2)=[CH:23][C:14]2[C:15]([CH2:20][CH2:21][CH3:22])=[CH:16][C:17](=[O:19])[O:18][C:13]=2[CH:12]=1

참가 물질

7

반응물 4

HCID 15413tert-Butyl methyl etherHCID 698734-PhenylpiperidineHCID 5460307FumarateHCID 199277386-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-propyl-2H-1-benzopyran-2-one

생성물 1

HCID 199277257-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-propyl-2H-1-benzopyran-2-one수율 54%

시약·촉매·용매 2

HCID 180Acetone용매HCID 887Methanol용매

실험 절차

Method A (20 h at 60° C.); starting materials: 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-propyl-2H-1-benzopyran-2-one (example 76) and 4-phenylpiperidine; yield 54%; fusion point 101°-102° C. (from TBME and petroleum ether). Fumarate: method E; yield 62%; fusion point 191°-194° C. (from acetone and methanol).

후처리

  1. customMethod A (20 h at 60° C.)

출처 및 근거

ORD 기록
ord-f6916d529fe9473aa2dc8d74fbd0b5a2
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

연결된 노트

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