N-bromobutanimide → 3-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyrazine

HRID 2233077노트

반응식

HRID 2233077 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[N:14][CH:13]=[CH:12][N:11]3[CH:16]=2)=[CH:4][CH:3]=1.[Br:17]N1C(=O)CCC1=O>C(Cl)Cl>[Br:17][C:16]1[N:11]2[CH:12]=[CH:13][N:14]=[CH:15][C:10]2=[N:9][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 32311372-(4-Fluorophenyl)imidazo[1,2-a]pyrazine

생성물 1

HCID 498448783-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyrazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-(4-fluorophenyl)imidazo[1,2-a]pyrazine (Preparation #2, 0.176 g, 0.783 mmol) in DCM (3 mL) was added N-bromosuccinimide (0.153 g, 0.862 mmol) dropwise. After about 20 minutes, the mixture was concentrated under reduced pressure and purified by flash silica gel chromatography using EtOAc as the eluent to yield the title compound (0.130 g, 54%>: LC/MS (Table 1, Method a) Rt=2.0 min; MS m/z: 294.2 (M+H)+.

후처리

  1. concentrationthe mixture was concentrated under reduced pressure
  2. custompurified by flash silica gel chromatography

출처 및 근거

ORD 기록
ord-53fd89d613044b3ea6bca610ac9040f4
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709468B2

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