Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate → (2-Bromo-4-methylthiazol-5-yl)methanol
반응식
[BH4-].[Na+].C([O:5][C:6]([C:8]1[S:12][C:11]([Br:13])=[N:10][C:9]=1[CH3:14])=O)C>C(O)C.O>[Br:13][C:11]1[S:12][C:8]([CH2:6][OH:5])=[C:9]([CH3:14])[N:10]=1참가 물질
5
실험 절차
sodium borohydride (1.2 g, 31.2 mmol) is carefully added to a solution of 2-Bromo-4-methyl-thiazole-5-carboxylic acid ethyl ester (3.6 g, 15.6 mmol) in ethanol (100 mL) and water (1 mL) and stirred at room temperature for twelve hours. The solvent is carefully removed under reduced pressure, the residue is taken up in ethylacetate and washed with water. The organic phase is separated and dried over MgSO4. The organic solvent is removed under reduced pressure to give 3.2 g of (2-Bromo-4-methyl-thiazol-5-yl)-methanol, which was used without further purification.
후처리
- customThe solvent is carefully removed under reduced pressure
- washwashed with water
- customThe organic phase is separated
- dry with materialdried over MgSO4
- customThe organic solvent is removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-0126dbe6ec424ef7b6a4942e2ba2dd08
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07709481B2
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