HCID 59295921, 화합물 → 2-(Carboxymethyl)-4-fluorobenzoic acid

HRID 2233394노트

반응식

HRID 2233394 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:17]([O:19]C)=[O:18])=[C:6]([CH:8](C(OC)=O)[C:9]([O:11]C)=[O:10])[CH:7]=1>Cl>[C:9]([CH2:8][C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[C:17]([OH:19])=[O:18])([OH:11])=[O:10]

참가 물질

3

반응물 1

HCID 59295921HCID 59295921, 화합물

생성물 1

HCID 3453952-(Carboxymethyl)-4-fluorobenzoic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
110 °C

실험 절차

A suspension of dimethyl [5-fluoro-2-(methoxycarbonyl)phenyl]malonate (1.80 g) in concentrated hydrochloric acid (25 ml) was heated at 110° C. for 48 h. The reaction was cooled and the subtitle compound collected as a white solid by filtration (1.0 g).

후처리

  1. temperatureThe reaction was cooled
  2. filtrationthe subtitle compound collected as a white solid by filtration (1.0 g)

출처 및 근거

ORD 기록
ord-2ca36af58f414a0ca311e19f37e4d677
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709500B2

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