Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Salicylic acid, hydrazide → ortho-(5-Methyl-1,3,4-oxadiazol-2-yl)-phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Salicylic acid, hydrazide | HCID 13637 | — |
| 반응물 | Triethyl orthoacetate | HCID 66221 | — |
| 용매 | 1-Propanol | HCID 1031 | — |
| 생성물 | ortho-(5-Methyl-1,3,4-oxadiazol-2-yl)-phenol | HCID 135979760 | 44.5% |
반응 단계
90 g (0.6 mole) of salicylic acid hydrazide and 388.8 g (2.4 moles) of triethyl orthoacetate in 500 ml of n-propanol are refluxed for 84 hours. When the mixture has cooled, the precipitate is filtered off and recrystallized from a mixture of toluene and petroleum ether. 47 g of colorless crystals (26.7% of theory) are obtained; melting point 74°-76° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04353904 |
| 출처 데이터셋 | uspto-grants-1982_10 |
| ORD ID | ord-eab5ff6792184edcb3686bb496315b85 |
| 출처 메모 | uspto-grants-1982_10 |