Water → 3-(4-Chlorophenoxy)-2-methyl-4-[(methylsulfonyl)amino]-1H-indole-1-acetic acid

HRID 2233745노트

반응식

HRID 2233745 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:33]=[CH:32][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:18][S:19]([CH3:22])(=[O:21])=[O:20])[N:11]([CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])[C:10]=2[CH3:31])=[CH:6][CH:5]=1.O>C1COCC1>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:18][S:19]([CH3:22])(=[O:20])=[O:21])[N:11]([CH2:23][C:24]([OH:26])=[O:25])[C:10]=2[CH3:31])=[CH:32][CH:33]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium Hydroxide2회HCID 866092313-(4-Chlorophenoxy)-2-methyl-4-[(methylsulfonyl)amino]-1H-indole-1-acetic acid, 1,1-dimethylethyl ester

생성물 1

HCID 116112153-(4-Chlorophenoxy)-2-methyl-4-[(methylsulfonyl)amino]-1H-indole-1-acetic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
55 °C

실험 절차

A solution of 1M sodium hydroxide (0.5 ml) was added to a stirred mixture of the product from step (v) (40 mg) in THF (1 ml). After 3 h, further 1M sodium hydroxide (1 ml) was added and the reaction heated at 55° C. for 16 h. Water (10 ml) was added and the THF evaporated under reduced pressure. The solution was acidified with 2M hydrochloric acid and the resulting solid filtered off and dried. Yield 24 mg

후처리

  1. customthe THF evaporated under reduced pressure
  2. filtrationthe resulting solid filtered off
  3. customdried

출처 및 근거

ORD 기록
ord-933f1f84ed0f47e7becc83c9e33fb5b8
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709521B2

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