Hydrochloric Acid → 6-(4-Aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-amine hydrochloride

HRID 2233841노트

반응식

HRID 2233841 반응식
[ClH:1].[NH2:2][C:3]1[N:8]=[C:7]([S:9][CH3:10])[N:6]=[C:5]([N:11]2[CH2:16][CH2:15][CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][CH2:12]2)[CH:4]=1>O1CCOCC1>[ClH:1].[NH2:17][CH:14]1[CH2:15][CH2:16][N:11]([C:5]2[N:6]=[C:7]([S:9][CH3:10])[N:8]=[C:3]([NH2:2])[CH:4]=2)[CH2:12][CH2:13]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68580046tert-Butyl 1-[6-amino-2-(methylthio)pyrimidin-4-yl]piperidin-4-ylcarbamate2회

생성물 1

HCID 685798436-(4-Aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-amine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4 N Hydrogen chloride in dioxane (3 ml) was added to tert-butyl 1-[6-amino-2-(methylthio)pyrimidin-4-yl]piperidin-4-ylcarbamate (Intermediate 45, 0.29 mg 0.86 mmol). The mixture was stirred at room temperature for 90 minutes. The solvent was removed in vacuo to afford the title compound (238 mg).

후처리

  1. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-2c5bb347f265437e81bf009cf111d789
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709503B2

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