Hydrochloric Acid → 5-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]-1,3,4-oxadiazol-2(5H)-one hydrochloride

HRID 2233846노트

반응식

HRID 2233846 반응식
Cl.[Cl:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11][CH2:10]2)[CH:6]=[C:5]([CH:23]2[N:27]=[N:26][C:25](=[O:28])[O:24]2)[CH:4]=1>O1CCOCC1>[ClH:2].[NH2:15][CH:12]1[CH2:13][CH2:14][N:9]([C:7]2[CH:6]=[C:5]([CH:23]3[O:24][C:25](=[O:28])[N:26]=[N:27]3)[CH:4]=[C:3]([Cl:2])[N:8]=2)[CH2:10][CH2:11]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86608245tert-Butyl 1-[6-chloro-4-(5-oxo-2,5-dihydro-1,3,4-oxadiazol-2-yl)pyridin-2-yl]piperidin-4-ylcarbamate2회

생성물 1

HCID 866082465-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]-1,3,4-oxadiazol-2(5H)-one hydrochloride수율 188.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4 N Hydrochloric acid in dioxane (3 ml) was added to tert-butyl 1-[6-chloro-4-(5-oxo-2,5-dihydro-1,3,4-oxadiazol-2-yl)pyridin-2-yl]piperidin-4-ylcarbamate (Intermediate 50, 0.12 mg, 0.32 mmol). The mixture was stirred at room temperature for 45 min, then concentrated in vacuo to afford the title compound (100 mg).

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5a9db109a7eb45e9a738bff809330a68
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709503B2

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