Hydrochloric Acid → N-(2-Oxoethyl)-3-phenethyloxy-N-phenyl-propanamide

HRID 2234174노트

반응식

HRID 2234174 반응식
C([O:3][CH:4](OCC)[CH2:5][N:6]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:7](=[O:19])[CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)C.Cl.ClCCl>O1CCOCC1>[O:3]=[CH:4][CH2:5][N:6]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:7](=[O:19])[CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 68702196N-(2,2-Diethoxyethyl)-3-phenethyloxy-N-phenyl-propanamide

생성물 1

HCID 86258421N-(2-Oxoethyl)-3-phenethyloxy-N-phenyl-propanamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
0 °C

실험 절차

N-(2,2-Diethoxyethyl)-3-phenethyloxy-N-phenyl-propanamide (Example 6a), 0.11 g) was dissolved in anhydrous dioxane (5 mL) and cooled to 0° C. Concentrated hydrochloric acid (0.3 mL) was added dropwise to the stirred solution at 0° C. The resultant reaction mixture was stirred at 0° C. for 2 hours. The reaction mixture was then poured into dichloromethane (10 mL) and washed with water (2×10 mL) and brine (10 mL). The organic layer was isolated, dried over anhydrous magnesium sulphate, filtered and concentrated to give the sub-titled compound (0.07 g) as a viscous oil.

후처리

  1. customThe resultant reaction mixture
  2. washwashed with water (2×10 mL) and brine (10 mL)
  3. customThe organic layer was isolated
  4. dry with materialdried over anhydrous magnesium sulphate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-de067b28e0094caca3bfcb6554d075ea
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709511B2

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