Ethyl Acetate → N-(2,2-Diethoxyethyl)-5-phenethyloxy-pentan-1-amine

HRID 2234179노트

반응식

HRID 2234179 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH2:16]([O:18][CH:19]([O:22][CH2:23][CH3:24])[CH2:20][NH2:21])[CH3:17].C(N(C(C)C)CC)(C)C.C(OCC)(=O)C>C(O)C>[CH2:16]([O:18][CH:19]([O:22][CH2:23][CH3:24])[CH2:20][NH:21][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:17]

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 695242,2-DiethoxyethylamineHCID 81531DiisopropylethylamineHCID 197980262-(5-Bromopentoxy)ethylbenzene

생성물 1

HCID 68701993N-(2,2-Diethoxyethyl)-5-phenethyloxy-pentan-1-amine수율 11.2%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
78 °C

실험 절차

2-(5-Bromopentoxy)ethylbenzene (1.5 g) was dissolved in ethanol (30 mL) and treated with 2,2-diethoxyethylamine (0.86 g) and diisopropylethylamine (1.8 mL) at room temperature. The reaction was stirred at 78° C. for 48 hours and was then poured into ethyl acetate (10 mL), washed with water (10 mL) and brine (10 mL). The organic layer was dried over anhydrous magnesium sulphate, filtered and concentrated in vacuo to give the sub-titled compound (0.2 g) as an oil.

후처리

  1. washwashed with water (10 mL) and brine (10 mL)
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-51f5bc0719ef414f8a7f7a946f96090f
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709511B2

반응 노트

불러오는 중…