참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methylacrylamide | HCID 14471 | — |
| 반응물 | (3,5-Dimethoxyphenyl)methanamine | HCID 420973 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-[(3,5-dimethoxyphenyl)methylamino]-N-methyl-propanamide | HCID 61860673 | — |
반응 단계
N-methylacrylamide (ABCR; 500 mg, 5.87 mmol) and 3,5-dimethoxybenzylamine (Aldrich; 0.98 mL, 6.46 mmol) were dissolved in ethanol (4 mL) and heated in a microwave at 140° C. for 45 minutes. The mixture was poured onto a 20 g SCX-2 column, washed with methanol and eluted with 3.5N NH3 in methanol. The product fractions were evaporated to the title compound as a yellow oil (1.3 g, 88%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07709471B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_05 |
|---|
| ORD ID | ord-1c1ae45c65f64fcd8a1df57615ec9650 |
|---|
| 출처 메모 | uspto-grants-2010_05 |
|---|
