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Hydrochloric Acid → (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride

HRID 2234454
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인쇄 미리보기

반응식

HRID 2234454 반응식
[CH3:1][N:2]1[CH2:6][CH2:5][C@@H:4]([NH:7]C(=O)OC(C)(C)C)[CH2:3]1.[ClH:15]>O1CCOCC1>[ClH:15].[ClH:15].[CH3:1][N:2]1[CH2:6][CH2:5][C@@H:4]([NH2:7])[CH2:3]1
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참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 45091942(R)-tert-Butyl 1-methylpyrrolidin-3-ylcarbamate2회

생성물 1

HCID 53256048(3R)-1-Methyl-3-PyrrolidinaMine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

tert-butyl N-[(3R)-1-methylpyrrolidin-3-yl]carbamate (Intermediate 185; 1.18 g, 5.67 mmol) was dissolved in 1,4-dioxane (10 mL) and 4M HCl in dioxane (10 mL) added. The mixture was stirred at room temperature for 1 hour and then concentrated to yield the title compound as a white hygroscopic solid (810 mg, 100%).

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-aef1212eac7d477da2f0730538cbdad5
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07709471B2

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