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Diethyl Ether → HCID 22821826, 화합물

HRID 223447
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HRID 223447 반응식
[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:28])[CH2:14][CH2:15][C@@H:16]3[C@@:21]4([CH3:27])[CH2:22][CH2:23][C@@H:24]([OH:26])[CH2:25][C@H:20]4[CH2:19][CH2:18][C@H:17]3[C@@H:12]2[CH2:11][CH2:10]1)[CH2:3][CH2:4][C:5](OC)=[O:6].[CH3:29][O:30][CH2:31][CH2:32][O:33][CH2:34]Cl.C(N(C(C)C)CC)(C)C.CCOCC>C(Cl)Cl>[CH3:29][O:30][CH2:31][CH2:32][O:33][CH2:34][O:26][C@@H:24]1[CH2:23][CH2:22][C@@:21]2([CH3:27])[C@H:20]([CH2:19][CH2:18][C@@H:17]3[C@@H:16]2[CH2:15][CH2:14][C@@:13]2([CH3:28])[C@H:12]3[CH2:11][CH2:10][C@@H:9]2[C@H:2]([CH3:1])[CH2:3][CH2:4][CH:5]=[O:6])[CH2:25]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 775901-(Chloromethoxy)-2-methoxyethaneHCID 81531DiisopropylethylamineHCID 92880Methyl lithocholate

생성물 1

HCID 22821826HCID 22821826, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methyl lithocholate is dissolved in methylene chloride, and β-methoxyethoxymethyl chloride and diisopropylethylamine are added. The mixture is stirred for four hours, ether added and washed with water. After drying the solvents are evaporated, the residue dissolved in toluene and the 24-ester group reduced to the 24-alcohol group with Vitride. The 24-alcohol then is oxidized with chromium trioxide-pyridine and the 3α-(β-methoxyethoxymethoxy)-5β-cholane-24-aldehyde obtained.

후처리

  1. washwashed with water
  2. customAfter drying the solvents
  3. customare evaporated
  4. dissolutionthe residue dissolved in toluene

출처 및 근거

ORD 기록
ord-56fa0286287b4e47be76810483ecb679
출처 데이터셋
uspto-grants-1982_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04354972

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