Lithium Hydroxide → 5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinecarboxylic acid

HRID 2234991노트

반응식

HRID 2234991 반응식
[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:10]=[C:11]([C:15]([O:17]CC)=[O:16])[CH:12]=[N:13][CH:14]=2)[CH2:3]1.[OH-].[Li+]>O1CCCC1>[CH3:8][C@H:6]1[NH:7][C@@H:2]([CH3:1])[CH2:3][N:4]([C:9]2[CH:10]=[C:11]([C:15]([OH:17])=[O:16])[CH:12]=[N:13][CH:14]=2)[CH2:5]1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 58988147Ethyl 5-[cis-3,5-dimethyl-1-piperazinyl]-3-pyridinecarboxylate

생성물 1

HCID 589881255-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinecarboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of ethyl 5-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinecarboxylate (D32) (800 mg, 3 mmol) in tetrahydrofuran (5 ml) was treated with 0.5M lithium hydroxide (12 ml, 6 mmol). The mixture was stirred at room temperature for 2 hours. The reaction was quenched with acetic acid (1 ml). The solvent was evaporated and the residue purified on SCX eluting with 2M ammonia in methanol to give the title compound (D33). MS (ES+) m/e 236 [M+H]+.

후처리

  1. customThe reaction was quenched with acetic acid (1 ml)
  2. customThe solvent was evaporated
  3. customthe residue purified on SCX
  4. washeluting with 2M ammonia in methanol

출처 및 근거

ORD 기록
ord-47e7385d00a8420ea36b40ab580a86e5
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713978B2

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