3-Chloro-1-propanol → 2,3-dihydro-8-(3-hydroxypropoxy)-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

HRID 22359

반응식

HRID 22359 반응식
C(=O)([O-])O.[K+].[OH:6][C:7]1[C:8]([O:21][CH3:22])=[CH:9][C:10]2[O:15][C:14](=[O:16])[C:13]3[CH2:17][CH2:18][CH2:19][C:12]=3[C:11]=2[CH:20]=1.Cl[CH2:24][CH2:25][CH2:26][OH:27]>C(O)(C)C>[OH:27][CH2:26][CH2:25][CH2:24][O:6][C:7]1[C:8]([O:21][CH3:22])=[CH:9][C:10]2[O:15][C:14](=[O:16])[C:13]3[CH2:17][CH2:18][CH2:19][C:12]=3[C:11]=2[CH:20]=1

참가 물질

5

반응물 3

HCID 123133-Chloro-1-propanolHCID 516893Potassium BicarbonateHCID 199276772,3-dihydro-8-hydroxy-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

생성물 1

HCID 199276482,3-dihydro-8-(3-hydroxypropoxy)-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one수율 58%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Method J (but using potassium hydrogencarbonate); Starting materials: 2,3-dihydro-8-hydroxy-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 109) and 3-chloro-1-propanol; yield 58%; fusion point 213°-215° C. (from isopropanol).

출처 및 근거

ORD 기록
ord-ce7b2c4cccf04c1c9483a6157345c6e0
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

연결된 노트

불러오는 중…