Diethyl Carbonate → Ethyl 2-(6-chloro-3-methylpyridin-2-YL)acetate
반응식
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[N:7]=1)[CH3:2].Cl[C:15]1N=C(C)C(C)=CC=1.[Li+].CC([N-]C(C)C)C.C(=O)(OCC)OCC>C1COCC1>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]1[C:11]([CH3:15])=[CH:10][CH:9]=[C:8]([Cl:12])[N:7]=1)[CH3:2]참가 물질
6
실험 절차
Following the same procedure described for the preparation of ethyl(6-chloro-2-pyridinyl)acetate (Example 469) and starting from 6-chloro-2,3dimethylpyridine (0.35 g, 2.5 mmol), LDA (5.17 mmol), and diethyl carbonate (0.75 mL, 6.2 mmol) in THF (10 mL), the title compound was obtained (0.15 g, 29%) as a yellow oil. 1H NMR (400 MHz, CDCl3): δ 7.42 (d, 1H), 7.15 (d, 1H), 4.18 (q, 2H), 3.84 (s, 2H), 2.29 (s, 3H), 1.27 (t, 3H); LC-MS: RT=2.30 min, (M+H)+ 214.2.
출처 및 근거
- ORD 기록
- ord-1067de62360c456c87fdceb3eaf29834
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07714004B2
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