2-Furan-3-yl-5-hydroxy-benzonitrile → 3-Aminomethyl-4-furan-3-yl-phenol

HRID 2236427노트

반응식

HRID 2236427 반응식
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][C:7]=2[C:8]#[N:9])=[CH:2]1>CCO.[Ni]>[NH2:9][CH2:8][C:7]1[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:6]=1[C:3]1[CH:4]=[CH:5][O:1][CH:2]=1

참가 물질

4

반응물 1

HCID 593001112-Furan-3-yl-5-hydroxy-benzonitrile

생성물 1

HCID 593002373-Aminomethyl-4-furan-3-yl-phenol수율 72%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

The 2-Furan-3-yl-5-hydroxy-benzonitrile obtained above is dissolved in EtOH and to which Raney Ni (1 g of suspension in water) is added. The mixture is then subjected to hydrogenation under H2 (50 psi) for 24 hours. After which Raney Ni is filtered off from celite and EtOH is removed to provide the title compound (40 mg, 72% for two steps). MS (ESI): 190 (M+1)+1, 173 (M+1-NH3)+1.

후처리

  1. additionis added
  2. filtrationAfter which Raney Ni is filtered off from celite and EtOH
  3. customis removed

출처 및 근거

ORD 기록
ord-5d8dbbbb82024049b6a36d5dd8dfd73f
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

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