Water → 5-Hydroxy-2-iodobenzonitrile

HRID 2236451노트

반응식

HRID 2236451 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].[I:10]Cl.O>C(O)(=O)C>[OH:1][C:2]1[CH:9]=[CH:8][C:7]([I:10])=[C:4]([CH:3]=1)[C:5]#[N:6]

참가 물질

5

반응물 3

HCID 962WaterHCID 133943-CyanophenolHCID 24640Iodine chloride

생성물 1

HCID 686960525-Hydroxy-2-iodobenzonitrile수율 7%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3-Hydroxy-benzonitrile (15 g, 0.126 mol) and iodine monochloride (28 g, 0.172 mol) is heated in acetic acid for 15 hours at 45° C. H2O is added to precipitate the product out. After the precipitate is collected and washed with Na2SO3, the residue is chromatographed with chloroform to get the product (2 g, 7%). MS (ESI): 244.0 (M−1)−1.

후처리

  1. customto precipitate the product out
  2. customAfter the precipitate is collected
  3. washwashed with Na2SO3
  4. customthe residue is chromatographed with chloroform

출처 및 근거

ORD 기록
ord-9b9b4aeb07e34314be368335e162467d
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

반응 노트

불러오는 중…