2-Furan-2-yl-5-hydroxy-benzonitrile → 3-Aminomethyl-4-furan-2-yl-phenol
반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][C:7]=1[C:8]#[N:9]>CCO.[Ni]>[NH2:9][CH2:8][C:7]1[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:6]=1[C:2]1[O:1][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
2-Furan-2-yl-5-hydroxy-benzonitrile (100 mg, 0.54 mmol) is dissolved in EtOH (10 mL) to which Raney Ni (excess) is added. The mixture is subjected to hydrogenation under H2 (50 psi) for overnight. The mixture is then filtered and solvent removed to afford the crude product, which is carried over to the next step without further purification.
후처리
- additionis added
- filtrationThe mixture is then filtered
- customsolvent removed
출처 및 근거
- ORD 기록
- ord-ca705e41da33488d8c0cd2a9c67c278a
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07713994B2
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