Hydrochloric Acid → 4-(3-Dimethylamino-propyl)-phenylamine hydrochloride
반응식
[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12]C(=O)C)=[CH:8][CH:7]=1.[ClH:17]>CO.Cl>[ClH:17].[CH3:16][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([NH2:12])=[CH:10][CH:11]=1참가 물질
5
반응 조건
- 온도
- 56 °C
실험 절차
To a solution of N-[4-(3-dimethylamino-propyl)-phenyl]-acetamide (0.50 mmol maximum) in methanol (8 mL) is added 20% aqueous hydrochloric acid solution. After 3½ hours of shaking at 56° C., an additional 2 drops of concentrated hydrochloric acid is added and shaking is continued for 3 days. The mixture is concentrated to give 4-(3-dimethylamino-propyl)-phenylamine hydrochloride, which is used without further purification in the following step.
후처리
- stirringshaking
- concentrationThe mixture is concentrated
출처 및 근거
- ORD 기록
- ord-09738256687847838214fd7865ea9833
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07713994B2
반응 노트
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