Methyl iodide → 4-(Methoxycarbonyl)-1-methylpyridin-1-ium iodide
반응식
[C:1]([O:9][CH3:10])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[I:11][CH3:12]>C1C=CC=CC=1>[I-:11].[CH3:10][O:9][C:1]([C:2]1[CH:7]=[CH:6][N+:5]([CH3:12])=[CH:4][CH:3]=1)=[O:8]참가 물질
4
반응 조건
- 온도
- 110 °C
실험 절차
To a solution of methyl isonicotinate (5.0 g, 36 mmol) in benzene (165 mL) is added iodomethane (4.5 mL, 72 mmol). The mixture is heated in a 110° C. oil bath for two hours and then allowed to cool to room temperature. The solid is collected by Büchner filtration, washed with hexanes and diethyl ether, and dried under house vacuum to give 4-methoxycarbonyl-1-methylpyridinium iodide (4.6 g, 46%).
후처리
- temperatureto cool to room temperature
- filtrationThe solid is collected by Büchner filtration
- washwashed with hexanes and diethyl ether
- customdried under house vacuum
출처 및 근거
- ORD 기록
- ord-e2cfd27a3cc549d4a7098ed6ac9adefa
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07713994B2
반응 노트
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