Hydrazine → N-(4-aminobenzyl)ethanesulfonamide

HRID 2236928노트

반응식

HRID 2236928 반응식
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][NH:9][S:10]([CH2:13][CH3:14])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O.NN>[Ni].CO>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][NH:9][S:10]([CH2:13][CH3:14])(=[O:12])=[O:11])=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 9321HydrazineHCID 47372696N-(4-nitrobenzyl)ethanesulfonamide

생성물 1

HCID 39243426N-(4-aminobenzyl)ethanesulfonamide

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

To the residue of the product from step 1 (0.25 mmol) is added methanol (350 μL), hydrazine (33 μL), and Raney-Nickel (10 mg). The reaction mixture is shaken at room temperature for 16 hours, then filtered and the solution concentrated to yield ethanesulfonic acid 4-amino-benzylamide, which is used as such for the subsequent reaction.

후처리

  1. filtrationfiltered
  2. concentrationthe solution concentrated

출처 및 근거

ORD 기록
ord-56f987b31f4c49e5bdcb88db96800530
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

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