5-Bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline → 5-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinolin-8-amine
반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:15])[CH2:7]2>C(O)C.[Ni]>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:15])[CH2:7]2참가 물질
4
실험 절차
To a solution of N-methyl-5-bromo-8-nitro-1,2,3,4-tetrahydroisoquinoline (III, 4.7 gm, 17.3 mmol) in ethanol (50 ml), Raney Nickel (solution in water, 1.5 g) was added. The reaction mixture was stirred at room temperature overnight under H2. The mixture was filtered through celite and solvent was removed under vacuum to give IV.
후처리
- filtrationThe mixture was filtered through celite and solvent
- customwas removed under vacuum
출처 및 근거
- ORD 기록
- ord-7c5288c394f14f128e7b45d721e163bd
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07718641B2
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