Hydrochloric Acid → N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride

HRID 2237472노트

반응식

HRID 2237472 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)[S:6]1(=[O:23])=[O:22].[CH3:24][NH2:25].Cl>>[ClH:1].[CH3:24][NH:25][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)[S:6]1(=[O:23])=[O:22]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 685840133-(3-chloropropyl)-1-(3-methylphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

생성물 1

HCID 68583132N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride

실험 절차

In an analogous manner to Example 1, step 8, 3-(3-chloropropyl)-1-(3-methylphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (21 mg) was reacted with methylamine and then treated with HCl to provide N-methyl-3-[1-(3-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzo thiadiazin-3-yl]propan-1-amine hydrochloride (18 mg):

출처 및 근거

ORD 기록
ord-a8d3699cf29842e495f5b09c66a19ff2
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07718652B2

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