Benzene → HCID 23081970, 화합물
반응식
I[C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14]/[CH:15]=[CH:16]/[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].CC(N=NC(C#N)(C)C)(C#N)C.C1C=CC=CC=1>>[C:18]1([CH2:17][CH2:16][CH:15]2[C:2]3[CH:3]=[C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH:10]=[CH:11][C:12]=3[O:13][CH2:14]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1참가 물질
4
실험 절차
To a solution of ethyl 3-iodo-4-{[(2E)-4-phenyl-but-2-enyl]-oxy}benzoate (13.42 g, 31.73 mmol) and AIBN (0.52 g, 3.17 mmol) in benzene (900 ml) tributyltin hydride (12 ml, 44.43 mol) was added at room temperature and the reaction mixture was warmed to reflux. After 2 h, the solvent was eliminated under vacuum. The residue was purified by flash chromatography on silica gel (petroleum ether/ethyl acetate=95/5) affording 9.14 g of the title compound (97% yield).
후처리
- temperaturethe reaction mixture was warmed to reflux