1-{Imidazo[1,2-a]pyridin-3-yl}ethan-1-one → HCID 59176797, 화합물

HRID 2238630노트

반응식

HRID 2238630 반응식
[N:1]1[CH:2]=[C:3]([C:10](=[O:12])[CH3:11])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12>COC(OC)N(C)C>[CH3:3][N:4]([CH3:9])/[CH:5]=[CH:11]/[C:10]([C:3]1[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]2=[N:1][CH:2]=1)=[O:12]

참가 물질

3

반응물 1

HCID 157181821-{Imidazo[1,2-a]pyridin-3-yl}ethan-1-one

생성물 1

HCID 59176797HCID 59176797, 화합물

시약·촉매·용매 1

HCID 78373Dimethylformamide dimethyl acetal용매

실험 절차

Unpurified imidazo[1,2-a]pyridin-3-ylethanone [1-1] was dissolved in 400 mL of N,N-dimethylformamide dimethylacetal, and overheated overnight under reflux. The dimethylformamide dimethylacetal was distilled off under reduced pressure, and then diethyl ether was added to the residue. Thus obtained solid was separated by filtration and dried under reduced pressure, to obtain 5.06 g of (E)-3-(dimethylamino)-1-imidazo[1,2-a]pyridin-3-yl-2-propen-1-one [1-2] as a light brown solid.

후처리

  1. temperatureoverheated overnight under reflux
  2. distillationThe dimethylformamide dimethylacetal was distilled off under reduced pressure
  3. additiondiethyl ether was added to the residue
  4. customThus obtained solid was separated by filtration
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-938b73aebbd24a2eaaab8319abce0f70
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07718801B2

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