N-bromobutanimide → 3-bromo-5H,6H,7H,8H-imidazo[1,2-a]pyridine

HRID 2238643노트

반응식

HRID 2238643 반응식
[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=12.[Br:10]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:10][C:3]1[N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]2=[N:1][CH:2]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 99892645H,6H,7H,8H-imidazo[1,2-a]pyridine

생성물 1

HCID 100356983-bromo-5H,6H,7H,8H-imidazo[1,2-a]pyridine수율 25.1%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

375 mg of the 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine [44-1] was dissolved in 10 mL of carbon tetrachloride, then 546 mg of N-bromosuccinimide was added, and the mixture was heated for 30 minutes under reflux. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography and then by preparative thin-layer chromatography sequentially, to obtain 155 mg of 3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine [44-2] as a pale yellow solid.

후처리

  1. temperaturethe mixture was heated for 30 minutes
  2. temperatureunder reflux
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-7fb63aabd4374955aa2831c51f16155d
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07718801B2

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