N-bromobutanimide → HCID 86616282, 화합물
반응식
[Cl:1][C:2]1[N:3]=[C:4]([CH2:11][CH2:12][CH2:13][NH2:14])[C:5]2[S:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[Br:15]N1C(=O)CCC1=O>C(#N)C>[Br:15][C:8]1[C:6]2[N:7]=[C:2]([Cl:1])[N:3]=[C:4]([CH2:11][CH2:12][CH2:13][NH2:14])[C:5]=2[S:10][CH:9]=1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
8.34 g (36.63 mmol) of (2-chlorothieno[3,2-d]pyrimidin-4-yl)propylamine (IV) is dissolved in 60 mL of acetonitrile and 7.89 g (44.32 mmol) of N-bromosuccinimide is added. The reaction mixture is stirred for 16 hours at ambient temperature and for 6 hours at 50° C. Then it is concentrated by evaporation and the residue is combined with water. The precipitate formed is suction filtered, washed, and dried. 7.25 g of product V (61%) is obtained as a powder.
후처리
- concentrationThen it is concentrated by evaporation
- customThe precipitate formed
- filtrationfiltered
- washwashed
- customdried
출처 및 근거
- ORD 기록
- ord-063e8fde9b2648b78c0aa2dbd7be305f
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07723341B2
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