Water → HCID 59305034, 화합물

HRID 2240253노트

반응식

HRID 2240253 반응식
[OH-].[Na+].[F:3][C:4]1[C:12]2[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=3[F:23])=[CH:10][CH:9]=[N:8][C:7]=2[N:6](S(C2C=CC(C)=CC=2)(=O)=O)[CH:5]=1.O.C(OCC)(=O)C>C(O)C>[F:3][C:4]1[C:12]2[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=3[F:23])=[CH:10][CH:9]=[N:8][C:7]=2[NH:6][CH:5]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 59304991HCID 59304991, 화합물

생성물 1

HCID 59305034HCID 59305034, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

0.4 ml of a 20% strength aqueous sodium hydroxide solution is added to a solution of 80 mg (0.18 mmol) of 3-fluoro-N-(2-fluoro-4-nitrophenyl)-1-[(4-methylphenyl)-sulfonyl]-1H-pyrrolo[2,3-b]pyridine-4-amine in 5 ml of ethanol, and the mixture is stirred overnight. The reaction solution is then poured into a mixture of water and ethyl acetate, and the aqueous phase is extracted two more times with ethyl acetate. Purification by preparative HPLC gives the target compound.

후처리

  1. extractionthe aqueous phase is extracted two more times with ethyl acetate
  2. customPurification by preparative HPLC
  3. customgives the target compound

출처 및 근거

ORD 기록
ord-74da6de7d8484f7ab9e285fae406a443
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723347B2

반응 노트

불러오는 중…