Sodium Hydroxide → HCID 68480823, 화합물

HRID 2240555노트

반응식

HRID 2240555 반응식
[OH-].[Na+:2].ClC1C=CC(S(C2C3C(=CC=C(C)C=3)N(CC(O)=O)C=2C)(=O)=O)=CC=1.[Cl:28][C:29]1[C:30](C#N)=[C:31]2[C:35](=[CH:36][CH:37]=1)[N:34]([CH2:38][C:39]([O:41]C)=[O:40])[C:33]([CH3:43])=[C:32]2[S:44]([C:47]1[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=1)(=[O:46])=[O:45]>C1COCC1>[Cl:28][C:29]1[CH:30]=[C:31]2[C:35](=[CH:36][CH:37]=1)[N:34]([CH2:38][C:39]([O-:41])=[O:40])[C:33]([CH3:43])=[C:32]2[S:44]([C:47]1[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=1)(=[O:45])=[O:46].[Na+:2]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 104072752-[3-(4-chlorophenyl)sulfonyl-2,5-dimethylindol-1-yl]acetic acidHCID 86605157HCID 86605157, 화합물

생성물 1

HCID 68480823HCID 68480823, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Sodium hydroxide (1M, 4.3 ml) was added to a solution of the product of example 1 part (c) (1.75 g) in THF (60 ml). The reaction mixture was stirred overnight and then concentrated in vacuo. The residue was recrystallised from water to give the title compound as a white solid.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue was recrystallised from water

출처 및 근거

ORD 기록
ord-649e2d82c664437ca5b7fcb7cb8878f8
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723373B2

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