Hydrochloric Acid → Ractopamine Hydrochloride

HRID 2240842노트

반응식

HRID 2240842 반응식
[CH3:1][CH:2]([NH:12][CH2:13][CH:14]([OH:22])[C:15]1[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=1)[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[ClH:23]>O>[CH3:1][CH:2]([NH:12][CH2:13][CH:14]([OH:22])[C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[ClH:23]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 56052Ractopamine

생성물 1

HCID 14010333Ractopamine Hydrochloride수율 50%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
72.5 °C

실험 절차

To 54.2 g (0.180 mol) of SR-ractopamine in 360 ml of water were added 360 ml of 2N hydrochloric acid and the reaction mixture was stirred under argon at 70-75° C. for 1 hour and then at 5° C. over night. The solvent was evaporated under reduced pressure, the obtained residue was co-evaporated with toluene (2×100 ml). The obtained solid was dried in vacuum to yield 53.88 g (89%) of RR/SR Ractopamine hydrochloride (D.R.: SR—49%; RR—50%).

후처리

  1. waitat 5° C. over night
  2. customThe solvent was evaporated under reduced pressure
  3. customThe obtained solid was dried in vacuum

출처 및 근거

ORD 기록
ord-9d975d694fed494b91eba86a27a732c5
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723392B2

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