Water → 1-(Benzo[d]oxazol-2-yl)cyclopropanecarboxylic acid

HRID 2241358노트

반응식

HRID 2241358 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1([C:13]([O:15]C)=[O:14])[CH2:12][CH2:11]1.C1COCC1.O.[Li+].[OH-]>C(OCC)(=O)C>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]1

참가 물질

6

반응물 4

HCID 962WaterHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 68518116Methyl 1-(benzo[d]oxazol-2-yl)cyclopropanecarboxylate

생성물 1

HCID 685133131-(Benzo[d]oxazol-2-yl)cyclopropanecarboxylic acid수율 81%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a stirred solution of methyl 1-(benzo[d]oxazol-2-yl)cyclopropanecarboxylate (0.132 g, 0.6077 mmol) in 3 mL 3:2 THF:H2O at room temperature under nitrogen was added LiOH (0.02911 g, 1.215 mmol). After stirring at ambient temperature overnight the reaction was diluted to 30 mL with ethyl acetate and washed with 2N HCl, water and brine. The organics were dried (MgSO4), filtered and concentrated to a white solid (100 mg, 81% yield).

후처리

  1. washwashed with 2N HCl, water and brine
  2. dry with materialThe organics were dried (MgSO4)
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-15b1df92e5eb48e2a9410c3b1482d797
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723330B2

반응 노트

불러오는 중…