HCID 59204985, 화합물 → 1-(2-Fluoro-4-nitrophenyl)piperidine-4-ylmethylamine

HRID 2241904노트

반응식

HRID 2241904 반응식
C(=[N:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][C:17]=2[F:25])[CH2:12][CH2:11]1)C1C=CC=CC=1>Cl>[F:25][C:17]1[CH:18]=[C:19]([N+:22]([O-:24])=[O:23])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:12][CH2:11][CH:10]([CH2:9][NH2:8])[CH2:15][CH2:14]1

참가 물질

3

반응물 1

HCID 59204985HCID 59204985, 화합물

생성물 1

HCID 592050221-(2-Fluoro-4-nitrophenyl)piperidine-4-ylmethylamine수율 98.5%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

1N aqueous hydrochloric acid (20 ml) was added to benzylidene[1-(2-fluoro-4-nitrophenyl)piperidine-4-ylmethyl]amine (compound of Reference Example 21; 1.15 g, 3.36 mmol), and the mixture was refluxed for 6 hours. The reaction mixture was washed with ethyl acetate and adjusted to pH=12 by addition of 2N aqueous sodium hydroxide. The water layer was saturated with sodium chloride and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (0.838 g, 98%) as a yellow solid.

후처리

  1. temperaturethe mixture was refluxed for 6 hours
  2. washThe reaction mixture was washed with ethyl acetate
  3. additionadjusted to pH=12 by addition of 2N aqueous sodium hydroxide
  4. extractionextracted with chloroform
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-05a0af01464f43a8a51e86e304bd3a47
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671058B2

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