4-(4-Nitro-2-(trifluoromethyl)phenyl)morpholine → 4-Morpholino-3-(trifluoromethyl)aniline

HRID 2241911노트

반응식

HRID 2241911 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[C:6]([C:16]([F:19])([F:18])[F:17])[CH:5]=1)([O-])=O>[Pt](=O)=O.CO>[O:13]1[CH2:12][CH2:11][N:10]([C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][C:6]=2[C:16]([F:18])([F:19])[F:17])[CH2:15][CH2:14]1

참가 물질

4

반응물 1

HCID 6128564-(4-Nitro-2-(trifluoromethyl)phenyl)morpholine

생성물 1

HCID 27713294-Morpholino-3-(trifluoromethyl)aniline수율 58%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

A mixture of 4-[4-nitro-2-(trifluoromethyl)phenyl]morpholine (compound of Reference Example 2; 1.20 g, 4.344 mmol), platinum(IV) oxide (0.10 g) and methanol (12 ml) was stirred at room temperature for 12.5 hours under hydrogen atmosphere. The reaction mixture was filtered and the residue obtained by evaporation of the solvent of the filtrate under reduced pressure was washed with n-hexane to give the title compound (0.62 g, 58%) as a colorless crystal.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe residue obtained by evaporation of the solvent of the filtrate under reduced pressure
  3. washwas washed with n-hexane

출처 및 근거

ORD 기록
ord-94bc5a01980a45948f8fcd0f231bdc88
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671058B2

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