Hydroxyamine hydrochloride → N'-hydroxy-3-(hydroxymethyl)benzimidamide

HRID 2242245노트

반응식

HRID 2242245 반응식
Cl.[OH:2][NH2:3].C(=O)(O)[O-].[Na+].[OH:9][CH2:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15]>CO>[OH:2][N:3]=[C:14]([C:13]1[CH:16]=[CH:17][CH:18]=[C:11]([CH2:10][OH:9])[CH:12]=1)[NH2:15]

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 27346773-(Hydroxymethyl)benzonitrile

생성물 1

HCID 74865044N'-hydroxy-3-(hydroxymethyl)benzimidamide수율 105.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Hydroxyl amine hydrochloride (2.29 g, 32.9 mmol) and sodium bicarbonate (5.52 g, 65.8 mmol) were added to 3-(hydroxymethyl)benzonitrile (2.19 g, 16.4 mmol) and methanol (30 mL) and stirred at reflux for 18 hours. The reaction mixture was cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo to give the title compound (2.88 g, 100% yield) as a solid.

후처리

  1. temperatureat reflux for 18 hours
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-50dca5ceb82844329cd1beb4a8475d8a
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671043B2

반응 노트

불러오는 중…