Hydrochloric Acid → Methyl 5-(tert-butyl)-2-methoxybenzoate

HRID 2242349노트

반응식

HRID 2242349 반응식
Cl.[C:2]([C:6]1[CH:7]=[CH:8][C:9]([O:15][CH3:16])=[C:10]([CH:14]=1)[C:11]([OH:13])=[O:12])([CH3:5])([CH3:4])[CH3:3].[CH3:17]O>>[CH3:17][O:12][C:11](=[O:13])[C:10]1[CH:14]=[C:6]([C:2]([CH3:5])([CH3:3])[CH3:4])[CH:7]=[CH:8][C:9]=1[O:15][CH3:16]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 70103155-Tert-Butyl-2-Methoxybenzoic Acid

생성물 1

HCID 15724682Methyl 5-(tert-butyl)-2-methoxybenzoate수율 95%

실험 절차

Hydrogen chloride gas was bubbled for 5 min into a stirred solution of 5-tert-butyl-2-methoxybenzoic acid (5.00 g, 24.0 mmol) in methanol (100 ml) at 0° C., after which time the solution was heated under reflux for 17.5 h. The reaction was cooled, evaporated to dryness under reduced pressure and purified by chromatography on silica using diethyl ether as eluent to afford 5-tert-butyl-2-methoxybenzoic acid methyl ester as a pale cream solid (5.06 g, 95%).

후처리

  1. temperatureafter which time the solution was heated
  2. temperatureunder reflux for 17.5 h
  3. temperatureThe reaction was cooled
  4. customevaporated to dryness under reduced pressure
  5. custompurified by chromatography on silica

출처 및 근거

ORD 기록
ord-71d8ceecbad14df5be86f1c5ba47b85f
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671080B2

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