Hydrochloric Acid → Ethyl 3,4-dichlorophenylacetate

HRID 224288

반응식

HRID 224288 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH2:14](O)[CH3:15]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:14][CH3:15])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 798743,4-Dichlorophenylacetic acid

생성물 1

HCID 2737422Ethyl 3,4-dichlorophenylacetate

실험 절차

A solution of 59.5 g of 3,4-dichlorophenylacetic acid in 500 ml of absolute ethanol is saturated with anhydrous hydrogen chloride and then heated at reflux for 2 hours. The mixture is concentrated under reduced pressure to 200 ml, diluted with 200 ml of water and neutralized with concentrated ammonium hydroxide. This aqueous mixture is extracted 3 times with chloroform. Concentration and decolorization of the chloroform extracts gives ethyl 3,4-dichlorophenylacetate as a yellow oil.

후처리

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. concentrationThe mixture is concentrated under reduced pressure to 200 ml
  4. additiondiluted with 200 ml of water and neutralized with concentrated ammonium hydroxide
  5. extractionThis aqueous mixture is extracted 3 times with chloroform
  6. concentrationConcentration and decolorization of the chloroform

출처 및 근거

ORD 기록
ord-291ab04acfd64a1e845e3da713d14741
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04231935

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