Ethyl isocyanate → 1-(4-Bromopyridin-2-yl)-3-ethylurea

HRID 2243060노트

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HRID 2243060 반응식
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[N:9]([CH2:12][CH3:13])=[C:10]=[O:11]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:10]([NH:9][CH2:12][CH3:13])=[O:11])[CH:3]=1

참가 물질

4

반응물 2

HCID 8022Ethyl isocyanateHCID 6932822-Amino-4-bromopyridine

생성물 1

HCID 592083771-(4-Bromopyridin-2-yl)-3-ethylurea수율 76.2%

시약·촉매·용매 1

HCID 6212Chloroform용매

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온도
110 °C

실험 절차

To a mixture of 4-bromopyridin-2-amine (2 g, 11.56 mmol) in chloroform (10 mL), isocyanatoethane (0.913 mL, 11.56 mmol) was added, and the resulting reaction mixture was heated at 110° C. for 2 h. The reaction mixture was concentrated under reduced pressure and triturated with acetonitrile, then collected by filtered to give the title compound as a white solid (2.15 g).

후처리

  1. additionwas added
  2. customthe resulting reaction mixture
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customtriturated with acetonitrile
  5. customcollected
  6. filtrationby filtered

출처 및 근거

ORD 기록
ord-45a5880b52564e1bb2cf746037031595
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674801B2

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