Ethanol → 2-(4-Bromo-2,6-dimethylphenoxy)ethanol

HRID 2243533

반응식

HRID 2243533 반응식
[BH4-].[Na+].[Br:3][C:4]1[CH:16]=[C:15]([CH3:17])[C:7]([O:8][CH2:9][C:10](OCC)=[O:11])=[C:6]([CH3:18])[CH:5]=1.O1CCCC1.C(O)C>O>[Br:3][C:4]1[CH:5]=[C:6]([CH3:18])[C:7]([O:8][CH2:9][CH2:10][OH:11])=[C:15]([CH3:17])[CH:16]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 8028TetrahydrofuranHCID 875019Ethyl (4-bromo-2,6-dimethylphenoxy)acetateHCID 4311764Sodium borohydride

생성물 1

HCID 537074432-(4-Bromo-2,6-dimethylphenoxy)ethanol수율 97.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium borohydride (0.21 g) was added to a mixture of ethyl (4-bromo-2,6-dimethylphenoxy)acetate (0.78 g), tetra hydro-furan (5 mL) and ethanol (5 mL), and the mixture was stirred at room temperature for 4 hrs. The reaction mixture was diluted with water, and extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/2) to afford the title compound (0.65 g).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure
  5. customthe residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/2)

출처 및 근거

ORD 기록
ord-a73e2dc2a81e4c2eb02be131670c8c96
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674938B2

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