Hydrazine hydrate (1:1) → 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbohydrazide

HRID 2243889노트

반응식

HRID 2243889 반응식
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]([CH3:11])[C:7](=[O:12])[CH:6]=1)=O.O.[NH2:14][NH2:15]>C(O)C>[CH3:11][N:8]1[CH:9]=[CH:10][C:5]([C:3]([NH:14][NH2:15])=[O:2])=[CH:6][C:7]1=[O:12]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 819408Methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

생성물 1

HCID 431322131-Methyl-2-oxo-1,2-dihydropyridine-4-carbohydrazide수율 78.3%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
78 °C

실험 절차

The title compound of example 24 (4.0 g, 23.9 mmol) was dissolved in ethanol (50 mL). Hydrazine hydrate (5.8 mL, 119 mmol) was added and the reaction was stirred at 78° C. for 3 hours. The reaction mixture was then cooled to room temperature and the product was filtered off to give 3.13 g (78% yield) of the title compound as a light yellow solid.

후처리

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. filtrationthe product was filtered off

출처 및 근거

ORD 기록
ord-6e985cf53a5940caab4753b815de760d
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678796B2

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