Hydrazine hydrate (1:1) → 3-[1-(4-Fluoro-phenyl)-5-trifluoromethyl-1H-pyrazol-4-yl]-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine
반응식
[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18]([C:20]1[CH:21]=[N:22][N:23]([C:29]2[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=2)[C:24]=1[C:25]([F:28])([F:27])[F:26])=O)(=O)OC.O.[NH2:37][NH2:38]>>[F:35][C:32]1[CH:33]=[CH:34][C:29]([N:23]2[C:24]([C:25]([F:28])([F:27])[F:26])=[C:20]([C:18]3[N:38]=[N:37][C:2]4[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=4[CH:17]=3)[CH:21]=[N:22]2)=[CH:30][CH:31]=1참가 물질
4
반응물 3
생성물 1
실험 절차
off-white solid. MS (EI): 390.1 (M+). Prepared from cyclooctane-1,2-dione, {2-[1-(4-Fluoro-phenyl)-5-trifluoromethyl-1H-pyrazol-4-yl]-2-oxo-ethyl}-phosphonic acid dimethyl ester, hydrazine monohydrate.