Acetic Anhydride → HCID 58674939, 화합물

HRID 2244418노트

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HRID 2244418 반응식
[CH3:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([N+:9]([O-:11])=[O:10])[N:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][C:2]1[C:7]([O:8][C:12](=[O:14])[CH3:13])=[CH:6][CH:5]=[C:4]([N+:9]([O-:11])=[O:10])[N:3]=1

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 217660202-Methyl-6-nitro-3-pyridinol

생성물 1

HCID 58674939HCID 58674939, 화합물수율 77%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 2-methyl-6-nitro-pyridin-3-ol (0.77 g, 5.00 mmol) in acetone (50.00 ml) was treated with acetic anhydride (1.00 g, 9.80 mmol) and potassium carbonate (2.07 g, 15.00 mmol). The mixture was stirred for 1 h at room temperature then filtered, washing with acetone. The solvent was removed, yielding acetic acid 2-methyl-6-nitro-pyridin-3-yl ester (0.75 g, 77%) as a white solid, MS (ISP): m/e=196.1 (M+), which was used crude.

후처리

  1. filtrationthen filtered
  2. washwashing with acetone
  3. customThe solvent was removed

출처 및 근거

ORD 기록
ord-8139debaada54c938bd7142147648bcc
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678815B2

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