Hydrochloric Acid → 5-(difluoromethyl)pyridin-3-amine

HRID 2244461노트

반응식

HRID 2244461 반응식
C(OC(=O)[NH:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([CH:14]([F:16])[F:15])[CH:13]=1)(C)(C)C.Cl.CCO>C(OCC)(=O)C>[F:15][CH:14]([F:16])[C:12]1[CH:13]=[C:8]([NH2:7])[CH:9]=[N:10][CH:11]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 684058001,1-Dimethylethyl N-[5-(difluoromethyl)-3-pyridinyl]carbamate

생성물 1

HCID 552855075-(difluoromethyl)pyridin-3-amine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

(5-Difluoromethyl-pyridin-3-yl)-carbamic acid tert-butyl ester (0.30 g, 1.2 mmol) was dissolved in 10 ml ethyl acetate and 8M HCl in EtOH (3 ml, 25 mmol) were added. The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was quenched by addition of 20 ml sat. NaHCO3 solution and extracted three time with 50 ml ethyl acetate. The organic phases were pooled, dried with sodium sulfate and evaporated. The title compound was obtained as a brown oil (0.158 g, 89%).

후처리

  1. customThe reaction mixture was quenched by addition of 20 ml sat. NaHCO3 solution
  2. extractionextracted three time with 50 ml ethyl acetate
  3. dry with materialdried with sodium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-50acdfd076024512a0153b6513d41238
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678815B2

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