Sodium Hydroxide → 1-Isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

HRID 2244621노트

반응식

HRID 2244621 반응식
[OH-].[Na+].[CH2:3]([N:7]1[CH:12]=[CH:11][C:10]([C:13]([O:15]C)=[O:14])=[CH:9][C:8]1=[O:17])[CH:4]([CH3:6])[CH3:5]>CO.C1COCC1>[CH2:3]([N:7]1[CH:12]=[CH:11][C:10]([C:13]([OH:15])=[O:14])=[CH:9][C:8]1=[O:17])[CH:4]([CH3:6])[CH3:5]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59214340HCID 59214340, 화합물

생성물 1

HCID 446005741-Isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid수율 81%

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

To a mixed solution was added a 1M aqueous NaOH solution (4.1 ml) of methyl 1-isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylate (430 mg) in CH3OH-THF (4 ml-3 ml). The solution was stirred at room temperature for 10 hours, and then concentrated under reduced pressure, and water (10 ml) was added, and subsequently 1M HCl was added thereto until pH becomes 3. The resulting solid was collected by filtration, washed with water, and dried under reduced pressure to obtain 1-isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid (325 mg) as white powders.

후처리

  1. concentrationconcentrated under reduced pressure, and water (10 ml)
  2. additionwas added
  3. additionsubsequently 1M HCl was added
  4. filtrationThe resulting solid was collected by filtration
  5. washwashed with water
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-8fed1637ad2c4ac682ff19acfd8a4e98
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678820B2

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