Hydrochloric Acid → HCID 316821, 화합물

HRID 224486

반응식

HRID 224486 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][N:3]=1.Cl.[N:9](OCC)=[O:10]>C(O)C>[CH:1](=[N:9][OH:10])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8026Ethyl NitriteHCID 189224-Methylpyrimidine

생성물 1

HCID 316821HCID 316821, 화합물수율 71%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

4-Methyl-pyrimidine (0.1 M) was added to 100 ml of ethanol containing 3.5 g (0.1 M) of HCl. While keeping the reaction mixture at 5° there was added over 60 minutes a solution of 9 g (0.12 M) of ethyl nitrite in 60 ml of ethyl alcohol, whereupon the whole was kept under stirring for 1 hour at room temperature. The thus formed 4-formyl-pyrimidine-oxime hydrochloride was separated by filtration, dissolved in water and the aqueous solution neutralized by adding Na2CO3. The title compound was finally obtained by filtration and drying. M.p. 154°-155°. Yield 71%.

후처리

  1. customat 5°
  2. customThe thus formed 4-formyl-pyrimidine-oxime hydrochloride was separated by filtration
  3. dissolutiondissolved in water
  4. additionby adding Na2CO3

출처 및 근거

ORD 기록
ord-0f6d3b02f5f144b39706e25be041f421
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04232156

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