1,2-Dichloroethane → HCID 11649425, 화합물

HRID 2244967

반응식

HRID 2244967 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH:12]([NH2:16])[C:13]([OH:15])=O)=[CH:3]1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1.[CH3:27][N:28]1[CH2:32][CH2:31][N:30]=[C:29]1[C:33]1[CH:38]=[CH:37][C:36]([NH2:39])=[CH:35][CH:34]=1.C(Cl)CCl>CN(C=O)C.O>[CH3:27][N:28]1[CH2:32][CH2:31][N:30]=[C:29]1[C:33]1[CH:38]=[CH:37][C:36]([NH:39][C:13](=[O:15])[CH:12]([CH2:11][C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:2]([CH3:1])[CH:3]=2)[NH:16][C:25]([NH:24][C:21]2[CH:22]=[CH:23][C:18]([Cl:17])=[CH:19][CH:20]=2)=[O:26])=[CH:35][CH:34]=1

참가 물질

7

반응물 4

HCID 111,2-DichloroethaneHCID 76934-Chlorophenyl IsocyanateHCID 981121-MethyltryptophanHCID 227288764-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamine

생성물 1

HCID 11649425HCID 11649425, 화합물수율 61.9%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a solution of DL-1-methyl-tryptophan (71 mg, 0.33 mmol) in DMF (4 mL), 4-chlorophenyl isocyanate (50 mg, 0.33 mmol) was added. The mixture was then stirred at room temperature overnight. It was filtered. To the filtrate, 4-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamine (150 mg, 0.86 mmol) and H2O (0.5 mL, to solubilize the amine) were added. To the solution, EDC (127 mg, 0.66 mmol) was added. After being stirred at room temperature overnight, the solution was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a powder (108 mg). MS 529.2 and 531.2 (M+H, Cl pattern).

후처리

  1. filtrationIt was filtered
  2. additionwere added
  3. stirringAfter being stirred at room temperature overnight
  4. concentrationthe solution was concentrated in vacuo
  5. customThe residue was purified by HPLC

출처 및 근거

ORD 기록
ord-aaf74f853ba04c9a9f7b0d724e2dd667
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678913B2

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