6-Amino-3-methyl-5-nitroso-1-phenylpyrimidine-2,4(1H,3H)-dione → 5,6-Diamino-3-methyl-1-phenyluracil

HRID 224584노트

반응식

HRID 224584 반응식
[NH2:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:6](=[O:14])[N:5]([CH3:15])[C:4](=[O:16])[C:3]=1[N:17]=O>CN(C=O)C.O=[Pt]=O>[NH2:17][C:3]1[C:4](=[O:16])[N:5]([CH3:15])[C:6](=[O:14])[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:2]=1[NH2:1]

참가 물질

4

반응물 1

HCID 127062666-Amino-3-methyl-5-nitroso-1-phenylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 110752755,6-Diamino-3-methyl-1-phenyluracil

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 6228Dimethylformamide용매

실험 절차

40.5 g of 6-amino-3-methyl-5-nitroso-1-phenyl-2,4-(1H, 3H)-pyrimidinedione (XVII) in 500 ml of DMF and in the presence of 0.3 g of PtO2 was the solution catalytically hydrogenated for 20 minutes at a pressure of 200 kPa. The reaction mixture was heated and the catalyst was filtered off. After cooling, crystals were filtered off and washed with DMF and water. Yield 21.4 g (XVIII). NMR

후처리

  1. temperatureThe reaction mixture was heated
  2. filtrationthe catalyst was filtered off
  3. temperatureAfter cooling
  4. filtrationcrystals were filtered off
  5. washwashed with DMF and water

출처 및 근거

ORD 기록
ord-baedd3dcaa8d4d59add7c0c3ecd6ac79
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04233303

반응 노트

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